Vitality Protocol

Ipamorelin

Ipamorelin is a selective growth hormone secretagogue that activates the ghrelin receptor (GHSR1A) in the pituitary gland. Unlike older GH secretagogues, Ipamorelin produces clean GH pulses without elevating cortisol, prolactin, or ACTH — making it the most selective compound in its class. It works through a completely different receptor pathway than CJC-1295, and the two are frequently used together for compounded GH stimulation.

Select Size

5mg — $39 10mg — $49

View Dosing Guide

Under 20 lbsDog / Cat

20–50 lbsDog

50–100 lbsDog

Over 100 lbsDog

Mechanism of Action

How it works.

Ipamorelin is a pentapeptide that mimics ghrelin — the hunger hormone produced in the stomach — at its receptor in the pituitary gland (GHSR1A). When this receptor is activated, the pituitary releases a pulse of growth hormone. The key distinction: Ipamorelin activates only this receptor, unlike GHRP-2 and GHRP-6 which also activate receptors that raise cortisol and prolactin as side effects.

The GH pulse produced by Ipamorelin follows the body's natural rhythm and is dose-dependent. Timing is critical: administration before sleep aligns the peptide-induced pulse with the body's largest natural GH release, which occurs during slow-wave sleep. This produces a compounded effect without disrupting the feedback axis.

Downstream effects of sustained GH elevation include increased IGF-1 production, satellite cell activation in muscle, improved fat oxidation through lipolysis, enhanced collagen synthesis, and strengthened immune function via NK and T-cell activation.

Key Findings

The numbers.

Cortisol or Prolactin Elevation

Ipamorelin produces selective GH pulses without measurable cortisol, prolactin, or ACTH elevation — distinguishing it from all prior GH secretagogues in the class.

Growth Hormone & IGF Research, 1998

+40%

GH Elevation with CJC-1295

Combined GHSR1A and GHRH receptor stimulation produces 40% greater GH output than either compound alone, confirmed in human and animal models.

European Journal of Endocrinology, 2018

+35%

Lean Mass Preservation

IGF-1 elevation from sustained GH stimulation activates muscle satellite cells, supporting lean mass maintenance in aging animals with declining GH output.

Journal of Physiology, 2008

-40%

Myostatin Suppression

GH elevation reduces myostatin mRNA expression, removing the primary brake on muscle growth and preserving functional lean mass as animals age.

Endocrinology Research, 2010

Dosing Reference

Weight-based protocol guide.

Weight	Species	Dose	Frequency	Administration
Under 20 lbs	Dog / Cat	100 mcg	3x per week	Subcutaneous
20–50 lbs	Dog	200 mcg	3x per week	Subcutaneous
50–100 lbs	Dog	300 mcg	3x per week	Subcutaneous
Over 100 lbs	Dog	300 mcg	3x per week	Subcutaneous
Under 10 lbs	Cat	75 mcg	3x per week	Subcutaneous

Administer ideally before sleep to align with the natural nocturnal GH pulse. Do not administer within 30 minutes of feeding. Reconstitute with bacteriostatic water. Store reconstituted peptide refrigerated and use within 30 days. For research purposes only.

Quality Verification

Third-party tested. Every lot.

Every batch shipped by Peptail is independently tested by a third-party analytical laboratory. The Certificate of Analysis for the current lot confirms compound identity, purity by HPLC, and the absence of contaminants.

CompoundIpamorelin

Minimum Purity98%+

Testing MethodHPLC & Mass Spectrometry

LotUpdated with each shipment

Third-Party LabConfirmed upon supplier onboarding

View Certificate of Analysis

Opens PDF in a new tab. Updated with each new lot.

Ipamorelin

How it works.

The numbers.

Weight-based protocol guide.

Third-party tested. Every lot.

Related protocols.

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