GHK-Cu is a naturally occurring copper peptide complex found in human plasma that declines sharply after age 60. It activates over 4,000 human genes, promotes collagen and elastin synthesis, stimulates wound healing, and reduces chronic inflammation. For companion animals, it is the most direct intervention for coat degradation, skin thinning, and age-related tissue decline.
Shop Now View Dosing GuideGHK-Cu activates fibroblasts — the cells responsible for producing collagen, elastin, and glycosaminoglycans. Declining fibroblast activity is the primary driver of skin thinning, coat degradation, and slowed wound healing in aging animals. GHK-Cu restores this activity directly, producing measurable increases in collagen synthesis within weeks.
At the genomic level, GHK-Cu has been shown to activate genes associated with tissue repair and regeneration while downregulating genes associated with inflammation and oxidative stress. A 2010 analysis identified GHK-Cu as one of the most potent gene-expression modulators known, affecting pathways involved in metabolism, inflammation, nerve regeneration, and DNA repair.
GHK-Cu also promotes antioxidant enzyme production (superoxide dismutase, catalase) and chelates free copper ions, reducing copper-mediated oxidative damage in aging tissue.
| Weight | Species | Dose | Frequency | Administration |
|---|---|---|---|---|
| Under 20 lbs | Dog / Cat | 0.5 mg/kg | Once daily | Subcutaneous or topical |
| 20–50 lbs | Dog | 0.5–1 mg/kg | Once daily | Subcutaneous or topical |
| 50–100 lbs | Dog | 1 mg/kg | Once daily | Subcutaneous or topical |
| Over 100 lbs | Dog | 1 mg/kg | Once daily | Subcutaneous or topical |
| Under 10 lbs | Cat | 0.25 mg/kg | Once daily | Subcutaneous or topical |