Epithalon (Epitalon) is a synthetic tetrapeptide developed by the St. Petersburg Institute of Bioregulation and Gerontology. It is one of the most studied longevity peptides in academic literature, with documented effects on telomerase activation, telomere length maintenance, and lifespan extension across multiple species.
Shop Now View Dosing GuideEpithalon activates telomerase — the enzyme responsible for maintaining telomere length during cell division. Telomeres are the protective caps on the ends of DNA strands. With each cell division, telomeres shorten. When they reach a critical minimum length, cells enter senescence: they stop dividing and begin secreting inflammatory cytokines that degrade surrounding tissue.
By activating telomerase, Epithalon slows this shortening process. Cells maintain their division capacity longer, reducing the accumulation of senescent cells and the chronic inflammation they produce.
Epithalon also regulates the pineal gland's melatonin production, restoring circadian rhythm function that degrades with age. Melatonin is one of the body's most potent antioxidants — its restoration has downstream effects on sleep quality, immune function, and oxidative stress markers.
| Weight | Species | Dose | Frequency | Administration |
|---|---|---|---|---|
| Under 20 lbs | Dog / Cat | 50 mcg/kg | Once daily × 10 days | Subcutaneous |
| 20–50 lbs | Dog | 100 mcg/kg | Once daily × 10 days | Subcutaneous |
| 50–100 lbs | Dog | 100 mcg/kg | Once daily × 10 days | Subcutaneous |
| Over 100 lbs | Dog | 100–150 mcg/kg | Once daily × 10 days | Subcutaneous |
| Under 10 lbs | Cat | 50 mcg/kg | Once daily × 10 days | Subcutaneous |